Observed Tightening of Tropical Ascent in Recent Decades and Linkage to Regional Precipitation Changes

Climate models predict that the tropical ascending region should tighten under global warming, but observational quantification of the tightening rate is limited. Here we show that the observed spatial extent of the relatively moist, rainy and cloudy regions in the tropics associated with large‐scale ascent has been decreasing at a rate of −1%/decade (−5%/K) from 1979 to 2016, resulting from combined effects of interdecadal variability and anthropogenic forcings, with the former contributing more than the latter. The tightening of tropical ascent is associated with an increase in the occurrence frequency of extremely strong ascent, leading to an increase in the average precipitation rate in the top 1% of monthly rainfall in the tropics. At the margins of the convective zones such as the Southeast Amazonia region, the contraction of large‐scale ascent is related to a long‐term drying trend about −3.2%/decade in the past 38 years

Honey bee maternal effects improve worker performance and reproductive ability in offspring

Maternal effects are an evolutionary strategy used to improve offspring quality. In an example of maternal effects in honey bees (Apis mellifera), mother queens produce larger eggs in queen cells than in worker cells in order to breed better daughter queens. In our current study, morphological indexes, reproductive tissues, and the egg-laying ability of newly reared queens reared with eggs laid in queen cells (QE), eggs laid in worker cells (WE), and 2-day-old larvae in worker cells (2L) were evaluated. In addition, morphological indexes of offspring queens and working performance of offspring workers were examined. The thorax weight, number of ovarioles, egg length, and number of laid eggs and capped broods of QE were significantly higher than those of WE and 2L, indicating that the reproductive capacity of QE group was better than that of other groups. Furthermore, offspring queens from QE had larger thorax weights and sizes than those from the other two groups. Offspring worker bees from QE also had larger body sizes and greater pollen-collecting and royal jelly-producing abilities than those of other two groups. These results demonstrate that honey bees display profound maternal effects on queen quality that can be transmitted across generations. These findings provide a basis for improving queen quality, with implications in apicultural and agricultural production

IPC04-0590 INSPECTION OF HOLLOW SUCKER ROD BY USING GUIDED WAVE

ABSTRACT Based on cylindrical guided wave technology, a new designed piezoelectric ring was presented here and it was put on the cross section of the hollow sucker rod's end to excite or receive guided waves in the hollow sucker rod. By selecting and exciting specific guided mode at a given frequency, two artificial cracks (20 mm×1 mm×0.5 mm and 20 mm × 1mm×1mm), which located on the hollow sucker rod, can be found in time domain. Tie-ins in the hollow sucker rod increase the complexity of analyzing the received signals. An alternative method presented here is that a fast guide mode was selected and excited at a specific frequency. Then, the echo from cracks will appear the front of the echo from tie-ins of the hollow sucker rod in the received signals. Some conclusions proved that the new designed piezoelectric ring was more effective than previous piezoelectric transducers and it is feasible to utilize cylindrical guided wave to achieve nondestructive inspection on hollow sucker rod

Observed Tightening of Tropical Ascent in Recent Decades and Linkage to Regional Precipitation Changes

Climate models predict that the tropical ascending region should tighten under global warming, but observational quantification of the tightening rate is limited. Here we show that the observed spatial extent of the relatively moist, rainy and cloudy regions in the tropics associated with large‐scale ascent has been decreasing at a rate of −1%/decade (−5%/K) from 1979 to 2016, resulting from combined effects of interdecadal variability and anthropogenic forcings, with the former contributing more than the latter. The tightening of tropical ascent is associated with an increase in the occurrence frequency of extremely strong ascent, leading to an increase in the average precipitation rate in the top 1% of monthly rainfall in the tropics. At the margins of the convective zones such as the Southeast Amazonia region, the contraction of large‐scale ascent is related to a long‐term drying trend about −3.2%/decade in the past 38 years

Effects of larval exposure to the insecticide flumethrin on the development of honeybee (Apis mellifera) workers

Flumethrin is a widely used acaricide, but its improper use often leads to residue accumulation in honeybee colonies, thus threatening the health of honeybees, especially at the larval stage. Therefore, this study aimed to describe the direct toxicity of flumethrin on honeybee (Apis mellifera) larvae by conducting bioassays for immune and detoxification-related enzymes and transcriptome sequencing to determine the potential effects on newly emerged adults who were exposed to flumethrin during the larval stage. Results showed that the higher the concentration of flumethrin the honeybee larvae were exposed to, the greater the damage to the physiology of honeybee larvae and the newly emerged worker bees. When honeybee larvae were exposed to flumethrin concentrations higher than 0.01 mg/L, the activities of glutathione sulfur transferase and carboxylesterase were affected, and the metabolism-related genes in the head of newly emerged honeybees exposed to flumethrin during the larval stage were down-regulated. Flumethrin concentration higher than 0.1 mg/L significantly increased mixed-functional oxidase content in honeybee larvae, reduced the larval survival rate, and down-regulated the expression levels of olfactory-related and antioxidant-related genes in newly emerged honeybees. Furthermore, a flumethrin concentration of 1 mg/L significantly down-regulated the expression levels of immune and detoxification-related genes in newly emerged honeybees. These findings provide a comprehensive understanding of the response of honeybee larvae to sublethal flumethrin toxicity and could be used to further investigate the complex molecular mechanisms in honeybees under pesticide stress

Applying Satellite Observations of Tropical Cyclone Internal Structures to Rapid Intensification Forecast With Machine Learning

Tropical cyclone (TC) intensity change is controlled by both environmental conditions and internal storm processes. We show that TC 24‐hr subsequent intensity change (DV24) is linearly correlated with the departures in satellite observations of inner‐core precipitation, ice water content, and outflow temperature from respective threshold values corresponding to neutral TCs of nearly constant intensity. The threshold values vary linearly with TC intensity. Using machine learning with the inner‐core precipitation and the predictors currently employed at the National Hurricane Center (NHC) for probabilistic rapid intensification (RI) forecast guidance, our model outperforms the NHC operational RI consensus in terms of the Peirce Skill Score for RI in the Atlantic basin during 2009–2014 by 37%, 12%, and 138% for DV24 ≥ 25, 30, and 35 kt, respectively. Our probability of detection is 40%, 60%, and 200% higher than the operational RI consensus, while the false alarm ratio is only 4%, 7%, and 6% higher

Polydatin Inhibits Formation of Macrophage-Derived Foam Cells

Rhizoma Polygoni Cuspidati, a Chinese herbal medicine, has been widely used in traditional Chinese medicine for a long time. Polydatin, one of the major active ingredients in Rhizoma Polygoni Cuspidati, has been recently shown to possess extensive cardiovascular pharmacological activities. In present study, we examined the effects of Polydatin on the formation of peritoneal macrophage-derived foam cells in Apolipoprotein E gene knockout mice (ApoE−/−) and explored the potential underlying mechanisms. Peritoneal macrophages were collected from ApoE−/− mice and cultured in vitro. These cells sequentially were divided into four groups: Control group, Model group, Lovastatin group, and Polydatin group. Our results demonstrated that Polydatin significantly inhibits the formation of foam cells derived from peritoneal macrophages. Further studies indicated that Polydatin regulates the metabolism of intracellular lipid and possesses anti-inflammatory effects, which may be regulated through the PPAR-γ signaling pathways

From Adversarial Arms Race to Model-centric Evaluation: Motivating a Unified Automatic Robustness Evaluation Framework

Textual adversarial attacks can discover models' weaknesses by adding semantic-preserved but misleading perturbations to the inputs. The long-lasting adversarial attack-and-defense arms race in Natural Language Processing (NLP) is algorithm-centric, providing valuable techniques for automatic robustness evaluation. However, the existing practice of robustness evaluation may exhibit issues of incomprehensive evaluation, impractical evaluation protocol, and invalid adversarial samples. In this paper, we aim to set up a unified automatic robustness evaluation framework, shifting towards model-centric evaluation to further exploit the advantages of adversarial attacks. To address the above challenges, we first determine robustness evaluation dimensions based on model capabilities and specify the reasonable algorithm to generate adversarial samples for each dimension. Then we establish the evaluation protocol, including evaluation settings and metrics, under realistic demands. Finally, we use the perturbation degree of adversarial samples to control the sample validity. We implement a toolkit RobTest that realizes our automatic robustness evaluation framework. In our experiments, we conduct a robustness evaluation of RoBERTa models to demonstrate the effectiveness of our evaluation framework, and further show the rationality of each component in the framework. The code will be made public at \url{https://github.com/thunlp/RobTest}.Comment: Accepted to Findings of ACL 202

Decoy receptor DcR1 is induced in a p50/Bcl3-dependent manner and attenuates the efficacy of temozolomide

Temozolomide is used widely to treat malignant glioma but the overall response to this agent is generally poor. Resistance to DNA damaging drugs such as temozolomide has been related to the induction of anti-apoptotic proteins. Specifically, the transcription factor NF-κB has been suggested to participate in promoting the survival of cells exposed to chemotherapy. To identify factors that modulate cytotoxicity in the setting of DNA damage, we used an unbiased strategy to examine the NF-κB-dependent expression profile induced by temozolomide. By this route, we defined the decoy receptor DcR1 as a temozolomide response gene induced by a mechanism relying upon p50/NF-κB1. A conserved NF-κB binding sequence (κB-site) was identified in the proximal promoter and demonstrated to be required for DcR1 induction by temozolomide. Loss-of-function and gain-of-function studies reveal that the atypical IκB protein, Bcl3, is also required for induction of DcR1 by temozolomide. Mechanistically, DcR1 attenuates temozolomide efficacy by blunting activation of the Fas receptor pathway in p53+/+ glioma cells. Intracranial xenograft studies show that DcR1 depletion in glioma cells enhances the efficacy of temozolomide. Taken together, our results show how DcR1 upregulation mediates temozolomide resistance, and provide a rationale for DcR1 targeting as a strategy to sensitize gliomas to this widely used chemotherapy

Decoy receptor DcR1 is induced in a p50/Bcl3-dependent manner and attenuates the efficacy of temozolomide

Temozolomide is used widely to treat malignant glioma but the overall response to this agent is generally poor. Resistance to DNA damaging drugs such as temozolomide has been related to the induction of anti-apoptotic proteins. Specifically, the transcription factor NF-κB has been suggested to participate in promoting the survival of cells exposed to chemotherapy. To identify factors that modulate cytotoxicity in the setting of DNA damage, we used an unbiased strategy to examine the NF-κB-dependent expression profile induced by temozolomide. By this route, we defined the decoy receptor DcR1 as a temozolomide response gene induced by a mechanism relying upon p50/NF-κB1. A conserved NF-κB binding sequence (κB-site) was identified in the proximal promoter and demonstrated to be required for DcR1 induction by temozolomide. Loss-of-function and gain-of-function studies reveal that the atypical IκB protein, Bcl3, is also required for induction of DcR1 by temozolomide. Mechanistically, DcR1 attenuates temozolomide efficacy by blunting activation of the Fas receptor pathway in p53+/+ glioma cells. Intracranial xenograft studies show that DcR1 depletion in glioma cells enhances the efficacy of temozolomide. Taken together, our results show how DcR1 upregulation mediates temozolomide resistance, and provide a rationale for DcR1 targeting as a strategy to sensitize gliomas to this widely used chemotherapy